Hormone excretion and liver function in the gynecomastia of leprosy.
نویسندگان
چکیده
Gynecomastia occurs in 7 to 15 per 100,000 of otherwise apparently healthy white males (38,40). It occurs commonly in the newborn, and some 40 per cent of boys show enlargement of the breasts during puberty. The influence of estrogens on the growth of breast-duct tissue is well known, as is the gynecomastia induced by excess exposure to estrogens. Gynecomastia is often associated with liver disease (12,22,23). Inactivation of circulating estrogens probably takes place in the liver (9,17). The incidence of gynecomastia in leprosy has been reported by Baptista (3) as being 8.6 per cent, and by Grabstald and Swan (16) as 19 per cent. Our series showed an incidence of 6 per cent in 600 lepromatous cases examined. No tuberculoid case was found to have gynecomastia. Lepromatous leprosy is a systemic disease, and primary and secondary lesions of the liver are a not uncommon finding (31). Coupled with this among our patients is the high carbohydrate, low protein diet of the Bantu, which might have a predisposing effect in the production of liver damage. For these reasons, and because the liver is probably linked with steroid metabolism, it was necessary in our study to establish liver function along with the hormone excretion values. We report here the hormone excretion and liver function tests of 18 cases of lepromatous patients showing gynecomastia (Figs. 1 and 2). These findings are compared with results found in 20 lepromatous cases not showing that condition, with values derived from 20 tuberculoid cases, and with a further set of values derived from 20 normal Bantu males.
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عنوان ژورنال:
- International journal of Leprosy
دوره 25 2 شماره
صفحات -
تاریخ انتشار 1957